Kent_N501Y_836.ml_annotated_collapsed_tree_v3 1798×3618 388 KBįigure 1 | Phylogenetic tree of the B.1.1.7 lineage and its nearest outgroup sequences, for samples collected up until 3. Of these 519 were sampled in Greater London, 555 in Kent, 545 in other regions of the UK including both Scotland and Wales, and 4 in other countries. As of 15th December, there are 1623 genomes in the B.1.1.7 lineage. Genomes belonging to lineage B.1.1.7 form a monophyletic clade that is well supported by a large number of lineage-defining mutations (Figure 1). B.1.1.7 infections have continued to be detected in the UK through early December 2020. The two earliest sampled genomes that belong to the B.1.1.7 lineage were collected on 20-Sept-2020 in Kent and another on 21-Sept-2020 from Greater London. The rapid growth of this lineage indicates the need for enhanced genomic and epidemiological surveillance worldwide and laboratory investigations of antigenicity and infectivity.
Mutation P681H is immediately adjacent to the furin cleavage site, a known location of biological significance.The spike deletion 69-70del has been described in the context of evasion to the human immune response but has also occurred a number of times in association with other RBD changes.Mutation N501Y is one of six key contact residues within the receptor-binding domain (RBD) and has been identified as increasing binding affinity to human and murine ACE2.Three of these mutations have potential biological effects that have been described previously to varying extents: The number of B.1.1.7 cases, and the number of regions reporting B.1.1.7 infections, are growing.ī.1.1.7 has an unusually large number of genetic changes, particularly in the spike protein. The B.1.1.7 lineage accounts for an increasing proportion of cases in parts of England. Several aspects of this cluster are noteworthy for epidemiological and biological reasons and we report preliminary findings below. This cluster has been growing rapidly over the past 4 weeks and since been observed in other UK locations, indicating further spread. Recently a distinct phylogenetic cluster (named lineage B.1.1.7) was detected within the COG-UK surveillance dataset. This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License. MRC-University of Glasgow Centre for Virus Research.Report written by: Andrew Rambaut 1, Nick Loman 2, Oliver Pybus 3, Wendy Barclay 4, Jeff Barrett 5, Alesandro Carabelli 6, Tom Connor 7, Tom Peacock 4, David L Robertson 8, Erik Volz 4, on behalf of COVID-19 Genomics Consortium UK (CoG-UK) 9. Preliminary genomic characterisation of an emergent SARS-CoV-2 lineage in the UK defined by a novel set of spike mutations
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